Experiment on genetic-free neuromodulation approach, known as infrared neural stimulation (INS)

Move2Treat aims to achieve three distinct breakthroughs:

Breakthrough 1: develop a theory of how we generate movement by investigating the neuronal population activity across central brain regions and the spinal cord.
Breakthrough 2: develop a novel bi-directional soft-fiber platform able to stimulate and record multiple signals from the brain and the spinal cord.
Breakthrough 3: validate the developed theory and neural interface in health and disease models.
This project explores disruptive science by developing a new brain-spinal cord interface to investigate the associated neuronal circuits.

Move2Treat envisions:

Propose implant aim to deliver the “pacemaker of the nervous system”
- Based on a minimally invasive, wireless, biocompatible, and soft multifunctional fiber-based neural interface
- Capable of mapping brain-spinal cord activity through simultaneous stimulation/recording in vivo and real-time
- Provides high spatial and temporal resolution
- Achieve a high-performance bi-directional interface
Explore genetic-free neuromodulation approach, known as infrared neural stimulation (INS)
- Relies on infrared light absorption to induce a neuronal response
- Offers a safe and effective way to control neuronal activities with high spatial resolution
- Eliminates the need for genetic manipulation or introduction of exogenous substances
Answer the following questions:
- How different neuronal circuits of the brain interact with the spinal cord?
- What spinal networks are involved in the “execution” of brain “commands”?

Our Mission:

Propose an approach that paves the way for a disruptive technological paradigm for the central and peripheral nervous system. Validate the new knowledge and developed interface in vivo based on stroke-diseased models, where movement is compromised. Upon successful realization and in vivo validation, laying the foundation for therapy of other major neurological movement diseases